Author: Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J
Title: Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections Document date: 2014_1_6
ID: qyflkmi9_63
Snippet: Five-year view The next 5 years will be focused on working to resolve the major gaps and key issues that could hinder or slow a pan-helminthic vaccine development program. One major goal will be spearheading a focused antigen discovery program for both Ascaris and Trichuris and their eventual down-selection as detailed above. Once the antigens are identified and expressed, they will enter a process development, characterization and initial stabil.....
Document: Five-year view The next 5 years will be focused on working to resolve the major gaps and key issues that could hinder or slow a pan-helminthic vaccine development program. One major goal will be spearheading a focused antigen discovery program for both Ascaris and Trichuris and their eventual down-selection as detailed above. Once the antigens are identified and expressed, they will enter a process development, characterization and initial stability assessment program. A main consideration will include designing a formulation that will support stability of not only the candidate Ascaris and Trichuris antigens but also the Human Hookworm Vaccine antigens. Another key endeavor will be to build on previous preclinical studies to establish a suitable animal model for the Pan-anthelmintic vaccine. This model would support both immunogenicity and preclinical efficacy studies of our vaccine candidates, as we move toward an investigational new drug filing and clinical trials. Such studies will be critical for determining if the protective immunity achieved for these helminth antigens in laboratory animals can translate to human medicine. No writing assistance was utilized in the production of this manuscript.
Search related documents:
Co phrase search for related documents- preclinical efficacy and protective immunity: 1, 2
- preclinical efficacy and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8
- preclinical efficacy and vaccine development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- preclinical study and previous preclinical study: 1
- preclinical study and protective immunity: 1
- preclinical study and vaccine candidate: 1, 2, 3, 4, 5
- preclinical study and vaccine development: 1, 2, 3, 4, 5
- process development and protective immunity: 1, 2, 3, 4, 5
- process development and Trichuris antigen: 1, 2
- process development and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- process development and vaccine development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- process development and vaccine development program: 1
- process development and year view: 1
- protective immunity and Trichuris antigen: 1, 2, 3
- protective immunity and vaccine candidate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70
- protective immunity and vaccine development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- stability assessment and vaccine candidate: 1
- Trichuris antigen and vaccine development: 1, 2
Co phrase search for related documents, hyperlinks ordered by date