Title: Age-related factors in cyclosporine-induced syngeneic graft-versus-host disease: regulatory role of marrow-derived T lymphocytes Document date: 1990_7_1
ID: wmjjoyso_34_2
Snippet: es from mature animals was due to a delicate balance ofautoreactivity and host resistance, thus maintaining active control (suppression) of the autoreactive cells, one would have expected to be able to transfer disease in an environment of reduced or absent host resistance, as shown by Cheney and Sprent (10) . Taken together, it seems likely that host resistance mediated by T lymphocytes from mature animals clonally inactivate the autoreactive ce.....
Document: es from mature animals was due to a delicate balance ofautoreactivity and host resistance, thus maintaining active control (suppression) of the autoreactive cells, one would have expected to be able to transfer disease in an environment of reduced or absent host resistance, as shown by Cheney and Sprent (10) . Taken together, it seems likely that host resistance mediated by T lymphocytes from mature animals clonally inactivate the autoreactive cells. Inactivation or induction ofdonal anergy is thought to be the major mechanism controlling autoreactive cells that have escaped clonal deletion mechanisms in the thymus (26).
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