Author: Park, Donghyun; Huh, Hee Jae; Kim, Yeon Jeong; Son, Dae-Soon; Jeon, Hyo-Jeong; Im, Eu-Hyun; Kim, Jong-Won; Lee, Nam Yong; Kang, Eun-Suk; Kang, Cheol In; Chung, Doo Ryeon; Ahn, Jin-Hyun; Peck, Kyong Ran; Choi, Sun Shim; Kim, Yae-Jean; Ki, Chang-Seok; Park, Woong-Yang
Title: Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus Document date: 2016_11_23
ID: xgp2vx6o_19
Snippet: Given the large number of cases that resulted from exposure to Patient 14, it was intriguing that Patient 14 displayed the highest intrapatient heterogeneity. Among the 10 singlenucleotide variants that were observed in more than one patient, six variants were present at frequencies >0% in Patient 14 (Fig. 2) . Thus, the majority of intra-and interpatient heterogeneity observed in different patients seemed to originate from the variants present i.....
Document: Given the large number of cases that resulted from exposure to Patient 14, it was intriguing that Patient 14 displayed the highest intrapatient heterogeneity. Among the 10 singlenucleotide variants that were observed in more than one patient, six variants were present at frequencies >0% in Patient 14 (Fig. 2) . Thus, the majority of intra-and interpatient heterogeneity observed in different patients seemed to originate from the variants present in Patient 14. Our results showed that intrapatient heterogeneity can be transmitted in some cases, indicating that humans can be simultaneously infected with more than one MERS-CoV.
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