Author: Bederka, Lydia H.; Bonhomme, Cyrille J.; Ling, Emily L.; Buchmeier, Michael J.
Title: Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization Document date: 2014_10_28
ID: wbh06gzb_3
Snippet: Generally, signal peptides are short, extended amino-terminal sequences found within secreted or transmembrane proteins whose function is to direct nascent proteins to the ER for maturation via the secretory pathway (25) . Few viruses possess signal sequences that serve additional functions. The Ebola virus signal peptide was shown to modulate the extent of GP glycosylation, thereby moderating the extent of glycoprotein interaction with DC-SIGN/R.....
Document: Generally, signal peptides are short, extended amino-terminal sequences found within secreted or transmembrane proteins whose function is to direct nascent proteins to the ER for maturation via the secretory pathway (25) . Few viruses possess signal sequences that serve additional functions. The Ebola virus signal peptide was shown to modulate the extent of GP glycosylation, thereby moderating the extent of glycoprotein interaction with DC-SIGN/R (26) . Additionally, the HIV-1 Env protein signal peptide is thought to regulate glycoprotein folding and maturation (27) . In a nonviral model, the prion protein signal peptide interacts with the transmembrane domain for correct protein expression and membrane orientation (28) .
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