Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_24
Snippet: Togo et al. [62] reported that aspirin and salicylate (both at 100-300 μM) increased LTC 4 production by the RBL-2H3 mast cell line and mouse bone marrow-derived mast cells, and suggested that the mechanism involved calcium influx following activation of cytosolic phospholipase A 2 . We cannot conclude whether their observation corresponds with ours or not, and it is also unclear whether the effect of these NSAIDs is related to AERD......
Document: Togo et al. [62] reported that aspirin and salicylate (both at 100-300 μM) increased LTC 4 production by the RBL-2H3 mast cell line and mouse bone marrow-derived mast cells, and suggested that the mechanism involved calcium influx following activation of cytosolic phospholipase A 2 . We cannot conclude whether their observation corresponds with ours or not, and it is also unclear whether the effect of these NSAIDs is related to AERD.
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