Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_37
Snippet: I found that the amino acid sequence of the acetylated by aspirin in COX (FSLKG from 529 to 533) [46] , is also in the primary protein structure [76] of human corona virus HKU1 near the nonstructural protein (nsp) 4 domain which has a similar amino acid alignment to nsp4 of murine hepatitis virus. I could not find a nomenclature for this 5 amino acid site in HKU1, and I cannot predict whether aspirin and other NSAIDs act via this site in humans......
Document: I found that the amino acid sequence of the acetylated by aspirin in COX (FSLKG from 529 to 533) [46] , is also in the primary protein structure [76] of human corona virus HKU1 near the nonstructural protein (nsp) 4 domain which has a similar amino acid alignment to nsp4 of murine hepatitis virus. I could not find a nomenclature for this 5 amino acid site in HKU1, and I cannot predict whether aspirin and other NSAIDs act via this site in humans.
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