Author: Chu, Ruiyin; Reczek, David; Brondyk, William
Title: Capture-stabilize approach for membrane protein SPR assays Document date: 2014_12_8
ID: ueofl0wn_3
Snippet: Peptide-based assays for anti-GPCR antibodies are convenient; however, they can only be used for analyzing antibodies recognizing linear epitopes. The conventional assay format lacks resolution as it can not distinguish between the three mAb clones we tested. Whereas the reversed assay format lacks accuracy due to the avidity effect. The development of a whole-receptor assay was able to address these issues......
Document: Peptide-based assays for anti-GPCR antibodies are convenient; however, they can only be used for analyzing antibodies recognizing linear epitopes. The conventional assay format lacks resolution as it can not distinguish between the three mAb clones we tested. Whereas the reversed assay format lacks accuracy due to the avidity effect. The development of a whole-receptor assay was able to address these issues.
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