Selected article for: "checkpoint signaling and mitotic checkpoint"
Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling
  • Document date: 2017_11_1
    • ID: i4yquw4k_36
    Snippet: Although deleting MAD1-NTD compromised mitotic checkpoint when examined using the mCherry-Mis12 fusions (Fig. 1) , mutating presumable MPS1 phosphorylation sites within MAD1-NTD had no impact on the mitotic checkpoint (Fig. 5) , and others found no requirement for MAD1 N-terminal 400 or 420 residues for MAD2 O-C conversion or checkpoint responses (14, 29) . This suggests that a functional critical region lies within (420-485) residues, which happ.....
    Document: Although deleting MAD1-NTD compromised mitotic checkpoint when examined using the mCherry-Mis12 fusions (Fig. 1) , mutating presumable MPS1 phosphorylation sites within MAD1-NTD had no impact on the mitotic checkpoint (Fig. 5) , and others found no requirement for MAD1 N-terminal 400 or 420 residues for MAD2 O-C conversion or checkpoint responses (14, 29) . This suggests that a functional critical region lies within (420-485) residues, which happens to contain a likely non-coiled coil structure (Fig. 1) . However, neither of the MAD1 fragments spanning (327-423) or (327-488) residues bind to MAD2 in vitro (Fig. 2) , indicating the positive effect of MAD1-NTD on the mitotic checkpoint signaling needs further clarification.

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