Author: Stäger, Simona; Rafati, Sima
Title: CD8(+) T Cells in Leishmania Infections: Friends or Foes? Document date: 2012_1_24
ID: uofygmeu_41
Snippet: Although understudied, CD8 + T cells appear to play an important role in the immune response to most Leishmania infections. Pilot studies in the murine model of VL have also demonstrated that adoptive transfer of antigen-specific CD8 + T cells (Polley et al., 2006) or reactivation of CD8 + T cell responses through a therapeutic vaccine (Joshi et al., 2009) results in the control of parasite growth. A better understanding of the mode of activation.....
Document: Although understudied, CD8 + T cells appear to play an important role in the immune response to most Leishmania infections. Pilot studies in the murine model of VL have also demonstrated that adoptive transfer of antigen-specific CD8 + T cells (Polley et al., 2006) or reactivation of CD8 + T cell responses through a therapeutic vaccine (Joshi et al., 2009) results in the control of parasite growth. A better understanding of the mode of activation, the specificity, and effector functions of the various CD8 + T cell subsets generated during Leishmania infections could ameliorate the design of vaccines and of novel therapeutic interventions.
Search related documents:
Co phrase search for related documents- immune response and Leishmania infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- immune response and Leishmania infection immune response: 1, 2, 3, 4
- immune response and murine model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48
- immune response and novel therapeutic intervention: 1, 2, 3, 4
- immune response and parasite growth: 1, 2, 3, 4, 5, 6
- immune response and pilot study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- immune response and therapeutic intervention: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43
- immune response and therapeutic vaccine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69
- immune response and vaccine design: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- important role and Leishmania infection: 1, 2
- important role and murine model: 1, 2, 3, 4, 5, 6, 7, 8
- important role and parasite growth: 1
- important role and pilot study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- important role and therapeutic intervention: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- important role and therapeutic vaccine: 1, 2, 3, 4, 5, 6, 7, 8
- important role and vaccine design: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- Leishmania infection and vaccine design: 1
- murine model and pilot study: 1, 2, 3, 4
- murine model and therapeutic intervention: 1, 2
Co phrase search for related documents, hyperlinks ordered by date