Author: Xing, Liang; Sun, Feng; Wang, Zhendong; Li, Yan; Yang, Zhifang; Wang, Fengshan; Zhai, Guangxi; Tan, Haining
Title: Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate Document date: 2019_4_10
ID: x8f598x2_20
Snippet: The TEM images of CS-ES2-AF and ES2-AF ( Figure 2A) show that all the particles are uniform, nanosized spheres. The average sizes of the CS-ES2-AF and ES2-AF particles were 144.20 nm and 130.20 nm, respectively ( Figure 2B ). The small particle size, as well as the uniform size distribution of the CS-ES2-AF nanoparticles, was suitable for the development of nanomedicines. The zeta potentials of CS-ES2-AF and ES2-AF were -34.00±4.53 mV and -7.50Â.....
Document: The TEM images of CS-ES2-AF and ES2-AF ( Figure 2A) show that all the particles are uniform, nanosized spheres. The average sizes of the CS-ES2-AF and ES2-AF particles were 144.20 nm and 130.20 nm, respectively ( Figure 2B ). The small particle size, as well as the uniform size distribution of the CS-ES2-AF nanoparticles, was suitable for the development of nanomedicines. The zeta potentials of CS-ES2-AF and ES2-AF were -34.00±4.53 mV and -7.50±4.07 mV, respectively, indicating that the conjugation with CS enhanced the stability of ES2-AF in the system. Based on this result, we can conclude that CS-ES2-AF can self-assemble into well-stabilized nanoparticles in aqueous solution. This structure enables the peptide to be encapsulated in the CS-formed nanoparticles,
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