Selected article for: "active fragment and VEGF binding"
Author: Xing, Liang; Sun, Feng; Wang, Zhendong; Li, Yan; Yang, Zhifang; Wang, Fengshan; Zhai, Guangxi; Tan, Haining
Title: Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate
  • Document date: 2019_4_10
    • ID: x8f598x2_32
    Snippet: In this study, the active fragment AF inhibited the binding of VEGF to its receptor. Because the AF peptide contains several aromatic amino acids, it has poor water solubility. ES2 peptide and water-soluble mucopolysaccharide CS were used to modify AF, which resulted in a modified product CS-ES2-AF with improved water solubility; thus, CS-ES2-AF inhibited the binding of VEGF to its receptor VEGFR1 better than ES2-AF. In addition, glycosylation co.....
    Document: In this study, the active fragment AF inhibited the binding of VEGF to its receptor. Because the AF peptide contains several aromatic amino acids, it has poor water solubility. ES2 peptide and water-soluble mucopolysaccharide CS were used to modify AF, which resulted in a modified product CS-ES2-AF with improved water solubility; thus, CS-ES2-AF inhibited the binding of VEGF to its receptor VEGFR1 better than ES2-AF. In addition, glycosylation could also increase the stability of ES2-AF in aqueous solution. 5 Compared to unmodified ES2-AF, the modified CS-ES2-AF was more stable at 37°C and, thus, showed better inhibition than ES2-AF, a result that could also be verified by CAM experiments.

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