Author: Borges, Marcos Carvalho; Castro, Luiza Antunes; da Fonseca, Benedito Antonio Lopes
Title: Chloroquine use improves dengue-related symptoms Document date: 2013_8_23
ID: s8tq6d68_22
Snippet: Although chloroquine has a narrow safety margin, it is usually well tolerated. Adverse effects, such as headache, nausea, malaise, dizziness, blurred vision, difficulty focusing, mild gastrointestinal upset and pruritus, may commonly occur. Severe toxicity, e.g., neuromyopathy, retinopathy and bone-marrow toxicity, is rare and may occur with long-term treatment and/ or as an idiosyncratic reaction (Taylor & White 2004 , Alkadi 2007 . Chloroquine .....
Document: Although chloroquine has a narrow safety margin, it is usually well tolerated. Adverse effects, such as headache, nausea, malaise, dizziness, blurred vision, difficulty focusing, mild gastrointestinal upset and pruritus, may commonly occur. Severe toxicity, e.g., neuromyopathy, retinopathy and bone-marrow toxicity, is rare and may occur with long-term treatment and/ or as an idiosyncratic reaction (Taylor & White 2004 , Alkadi 2007 . Chloroquine may worsen psoriasis, though is rarely associated with seizures and psychosis. Acute toxicity is most frequently found with therapeutic or high doses administered too rapidly by parenteral routes (AlKadi 2007) . Toxic effects are related to the ingested dose and a single dose of 20 mg/kg is considered toxic (Taylor & White 2004) . In this study, a safety dose of 600 mg per day for three days was used in adults and the side effects were unremarkable. Furthermore, the chloroquine dosage used in this study is very similar to the dosage used for vivax malaria treat-ment and, in our experience, side effects are rare with this treatment. However, considering the small number of patients, more studies are necessary to evaluate the safety of chloroquine in dengue patients.
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