Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_4
Snippet: Currently, up to 10% of Asians, 50% of Caucasians, and 90% of Africans carry at least one copy of the DG allele and thus can generate IFN-l4. Carriers of the DG allele have impaired ability to clear hepatitis C virus (HCV) infection (Prokunina-Olsson and others 2013; Aka and others 2014). Chronic HCV infection eventually increases the risk of death due to liver failure and liver cancer, but this process takes decades, thus improvement of HCV clea.....
Document: Currently, up to 10% of Asians, 50% of Caucasians, and 90% of Africans carry at least one copy of the DG allele and thus can generate IFN-l4. Carriers of the DG allele have impaired ability to clear hepatitis C virus (HCV) infection (Prokunina-Olsson and others 2013; Aka and others 2014). Chronic HCV infection eventually increases the risk of death due to liver failure and liver cancer, but this process takes decades, thus improvement of HCV clearance due to genetic inability to produce IFN-l4 could not be the reason for the positive selection observed for the rs368234815-TT allele (Key and others 2014) . The strength of this selection indicates that IFN-l4 might have interfered with clearance of other more deadly pathogens, suggesting that elucidation of IFN-l4 function could be important for understanding, prevention, and treatment of some existing and emerging infections.
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