Selected article for: "nucleic acid sequence and tiling probe set"
Author: Jabado, Omar J.; Liu, Yang; Conlan, Sean; Quan, P. Lan; Hegyi, Hédi; Lussier, Yves; Briese, Thomas; Palacios, Gustavo; Lipkin, W. I.
Title: Comprehensive viral oligonucleotide probe design using conserved protein regions
  • Document date: 2007_12_13
    • ID: xfzhn1n1_22
    Snippet: To gauge the performance of our probe selection algorithm, another comprehensive method was devised that used only nucleic acid sequence. Sequences in the Reference Sequence Viral Genomes project (38) are evenly distributed among viral families; therefore, we reasoned that probes derived from these sequences would provide broad coverage. To contrast with our method, we selected 60 nt oligonucleotides end-to-end along all viral genomic RefSeq sequ.....
    Document: To gauge the performance of our probe selection algorithm, another comprehensive method was devised that used only nucleic acid sequence. Sequences in the Reference Sequence Viral Genomes project (38) are evenly distributed among viral families; therefore, we reasoned that probes derived from these sequences would provide broad coverage. To contrast with our method, we selected 60 nt oligonucleotides end-to-end along all viral genomic RefSeq sequences (1701 viruses). This resulted in a tiling probe-set where the length of a sequence was proportional to the number of interrogating probes.

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