Selected article for: "antibody expression and gene expression"
Author: Feng, Mingqian; Bian, Hejiao; Wu, Xiaolin; Fu, Tianyun; Fu, Ying; Hong, Jessica; Fleming, Bryan D; Flajnik, Martin F; Ho, Mitchell
Title: Construction and next-generation sequencing analysis of a large phage-displayed V(NAR) single-domain antibody library from six naïve nurse sharks
  • Document date: 2018_11_7
    • ID: wc6k06sm_21
    Snippet: In conclusion, we have built a large, highly diverse phage-displayed V NAR library using B cells isolated from nurse sharks. It provides a new platform to discover single-domain antibodies for therapeutic and diagnostic applications. The EASeL library construction method described here may be applicable to the construction of other large gene expression libraries including antibody libraries derived from other species and T-cell receptors......
    Document: In conclusion, we have built a large, highly diverse phage-displayed V NAR library using B cells isolated from nurse sharks. It provides a new platform to discover single-domain antibodies for therapeutic and diagnostic applications. The EASeL library construction method described here may be applicable to the construction of other large gene expression libraries including antibody libraries derived from other species and T-cell receptors.

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