Author: Zhang, XiZhen; Wang, XiaoDan; Zhao, DongHai; Meng, XiangYu; Zhao, XingHong; Yu, XiangHui; Kong, Wei
Title: Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine Document date: 2011_12_16
ID: xxypq3wd_31
Snippet: The sera specificity was evaluated by immunoblotting. The results presented in Figure 5 demonstrate that antibodies were induced in response to vaccination. New epitopes were not produced and no changes in immunodominance were detected. HIV-1-Gag-specific antibody responses from all VLPs treatments (2.5-25 ïg) were higher than that obtained for 100 ïg DNA ( Figure 5A ). In contrast, the HIV-1-Env- specific antibody response from 0.5-25 ïg V.....
Document: The sera specificity was evaluated by immunoblotting. The results presented in Figure 5 demonstrate that antibodies were induced in response to vaccination. New epitopes were not produced and no changes in immunodominance were detected. HIV-1-Gag-specific antibody responses from all VLPs treatments (2.5-25 ïg) were higher than that obtained for 100 ïg DNA ( Figure 5A ). In contrast, the HIV-1-Env- specific antibody response from 0.5-25 ïg VLPs was about the same as that observed with 100 ïg DNA ( Figure 5B ).
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