Selected article for: "cell surface and immune system"
Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha
  • Document date: 2016_6_4
    • ID: y0x0quha_2
    Snippet: We previously reported that tumor necrosis factor (TNF)alpha is involved in the aggravation of FIP [17] [18] [19] . TNF-alpha binds to cell surface TNF receptors and induces various physiological activities [15, 23] . TNF-alpha plays a critical role in many aspects of immunity. However, the excessive production of TNF-alpha can lead to acute inflammation and immune system abnormalities in human and other animals. The involvement of TNF-alpha in a.....
    Document: We previously reported that tumor necrosis factor (TNF)alpha is involved in the aggravation of FIP [17] [18] [19] . TNF-alpha binds to cell surface TNF receptors and induces various physiological activities [15, 23] . TNF-alpha plays a critical role in many aspects of immunity. However, the excessive production of TNF-alpha can lead to acute inflammation and immune system abnormalities in human and other animals. The involvement of TNF-alpha in aggravating the symptoms of rheumatoid arthritis, psoriasis and inflammatory bowel disease has been reported [1, 9, 24] . Moreover, previous studies have described aggravation of the pathologies of viral infections (such as human immunodeficiency virus, influenza A virus, herpes simplex virus (HSV) and dengue virus infections) due to increased TNF-alpha production [5, 12, 14, 21, 25] . TNF-alpha was produced excessively by FIPV-infected macrophages. TNF-alpha was involved in lymphopenia and increase in the level of the cellular receptor of serotype II FIPV, aminopeptidase N (APN) [18, 19] . It is also reported that neutrophil apoptosis in cats with FIP was inhibited by TNF-alpha. This finding suggests neutrophilia in cats with FIP due to TNF-alpha-induced neutrophil survival [17] .

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