Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha Document date: 2016_6_4
ID: y0x0quha_28
Snippet: Single administration of mouse mAb 2-4 improved the survival time and quality of life of cats with FIP [4] ; however, single administration did not exhibit a therapeutic effect in some cats. It is known that single administration of an anti-fTNF-alpha drug is unlikely to exhibit a therapeutic effect on cats with FIP; thus, several administrations of mAb 2-4 are necessary for treatment. However, several administrations of mouse mAb may induce anap.....
Document: Single administration of mouse mAb 2-4 improved the survival time and quality of life of cats with FIP [4] ; however, single administration did not exhibit a therapeutic effect in some cats. It is known that single administration of an anti-fTNF-alpha drug is unlikely to exhibit a therapeutic effect on cats with FIP; thus, several administrations of mAb 2-4 are necessary for treatment. However, several administrations of mouse mAb may induce anaphylactic reactions, as described above. Moreover, mouse mAb is a xenogeneic protein for cats, suggesting that a feline anti-mouse antibody response is induced in cats treated with mouse mAb 2-4, decreasing the reactivity against fTNF-alpha and thus reducing the therapeutic effect. The possibility of feline anti-chimeric antibody production similar to the production of anti-mouse mAb 2-4 antibody cannot be ruled out due to the variable region of chimeric mAb 2-4 being derived from mouse protein.
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