Author: Bird, Grace; Braithwaite, Irene; Harper, James; McKinstry, Steven; Koorevaar, Iris; Fingleton, James; Semprini, Alex; Dilcher, Meik; Jennings, Lance; Weatherall, Mark; Beasley, Richard
Title: Protocol for a randomised, single-blind, two-arm, parallel-group controlled trial of the efficacy of rhinothermy delivered by nasal high flow therapy in the treatment of the common cold Document date: 2019_6_19
ID: x2xc1s14_40
Snippet: In contrast to the recent feasibility study, 'sham' rhinothermy will be used as the control rather than Vitamin C. The use of 'Sham' rhinothermy in the control arm will provide the advantage of masking participants to treatment allocation and will control for any placebo effect associated with the use of a rhinothermy device. The rationale for the 'sham' device settings is to produce a treatment which is unlikely to have any therapeutic effect. F.....
Document: In contrast to the recent feasibility study, 'sham' rhinothermy will be used as the control rather than Vitamin C. The use of 'Sham' rhinothermy in the control arm will provide the advantage of masking participants to treatment allocation and will control for any placebo effect associated with the use of a rhinothermy device. The rationale for the 'sham' device settings is to produce a treatment which is unlikely to have any therapeutic effect. For respiratory pathogens with temperature-dependent replication, a temperature of 31°C should not inhibit viral replication.
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