Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_5
Snippet: The occurrence of RAN translation and frameshifting challenge the common dogmas that the expansions of CAG, CGG and G 4 C 2 repeats located in non-coding sequences do not encode any proteins and that CAG repeat mutations located in polyGln ORFs express proteins only in one frame. These findings raise the possibility that the new proteins resulting from RAN translation and frameshifting can be ubiquitous and contribute to the pathogenesis of these.....
Document: The occurrence of RAN translation and frameshifting challenge the common dogmas that the expansions of CAG, CGG and G 4 C 2 repeats located in non-coding sequences do not encode any proteins and that CAG repeat mutations located in polyGln ORFs express proteins only in one frame. These findings raise the possibility that the new proteins resulting from RAN translation and frameshifting can be ubiquitous and contribute to the pathogenesis of these neurological disorders.
Search related documents:
Co phrase search for related documents- frameshifting ran translation and new protein: 1
- frameshifting ran translation and RAN translation: 1, 2, 3, 4, 5, 6, 7
- new protein and protein encode: 1, 2
- new protein and RAN translation: 1
- non coding sequence and protein encode: 1
Co phrase search for related documents, hyperlinks ordered by date