Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_57
Snippet: Since the discovery of CAG repeat frameshifting, important questions regarding its frequency, mechanism and role in pathogenesis have arisen. These questions include the following: What triggers the frameshifting? Does it depend on the length of the CAG repeat encoding the polyQ stretch? Is it cell-type specific? Is frameshifting limited only to SCA3 and HD? How do the frameshifted species modulate the aggregation of the remaining pool of protein.....
Document: Since the discovery of CAG repeat frameshifting, important questions regarding its frequency, mechanism and role in pathogenesis have arisen. These questions include the following: What triggers the frameshifting? Does it depend on the length of the CAG repeat encoding the polyQ stretch? Is it cell-type specific? Is frameshifting limited only to SCA3 and HD? How do the frameshifted species modulate the aggregation of the remaining pool of proteins with expanded polyQ tracts? What is the precise effect of the frameshifted proteins on the well-acknowledged toxicity of polyGlnbearing proteins?
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