Author: Rogers, J.; Schoepp, R.J.; Schröder, O.; Clements, T.L.; Holland, T.F.; Li, J.Q.; Li, J.; Lewis, L.M.; Dirmeier, R.P.; Frey, G.J.; Tan, X.; Wong, K.; Woodnutt, G.; Keller, M.; Reed, D.S.; Kimmel, B.E.; Tozer, E.C.
Title: Rapid discovery and optimization of therapeutic antibodies against emerging infectious diseases Document date: 2008_5_13
ID: xkx56h0o_56
Snippet: The 2978/10 antibody was further studied in vivo to determine its ability to inhibit viral replication in the lungs of aged mice. Initial studies demonstrated that exposure of aged LC S114W CDR3 AGC!TGG GSSM TM -51H8 LC T119V CDR3 ACG!GTT HuFR TM (61G4) -2978/15 Y116F, S114W, Y128M HuFR TM (61H4) -2703/15 S114W, Y128M HuFR TM (61H4) -2992/15 A56S, Y116F, S114W, Y128M HuFR TM (61G4) -2978/10 Y116F, S114W HuFR TM (61H4) -2703/10 S114W HuFR TM (61H4.....
Document: The 2978/10 antibody was further studied in vivo to determine its ability to inhibit viral replication in the lungs of aged mice. Initial studies demonstrated that exposure of aged LC S114W CDR3 AGC!TGG GSSM TM -51H8 LC T119V CDR3 ACG!GTT HuFR TM (61G4) -2978/15 Y116F, S114W, Y128M HuFR TM (61H4) -2703/15 S114W, Y128M HuFR TM (61H4) -2992/15 A56S, Y116F, S114W, Y128M HuFR TM (61G4) -2978/10 Y116F, S114W HuFR TM (61H4) -2703/10 S114W HuFR TM (61H4) -2702/10 A56S, Y116F HuFR TM (61G4) -2699/10 A56S, S114W
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