Selected article for: "cellular factor and gene expression"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_44
    Snippet: In this study we provided the first evidence for the requirement of CRTC1 coactivator for HBV transcription and replication. Our work contributes at least three new messages concerning the role of CRTC1 in HBV infection. First, CRTC1 protein was abundantly expressed in HBVinfected cells (Figure 1) . Second, CRTC1 and its homologs (CRTC2 and CRTC3) are recruited to the preS2 promoter and cccDNA to mediate transcriptional activation in cooperation .....
    Document: In this study we provided the first evidence for the requirement of CRTC1 coactivator for HBV transcription and replication. Our work contributes at least three new messages concerning the role of CRTC1 in HBV infection. First, CRTC1 protein was abundantly expressed in HBVinfected cells (Figure 1) . Second, CRTC1 and its homologs (CRTC2 and CRTC3) are recruited to the preS2 promoter and cccDNA to mediate transcriptional activation in cooperation with CREB (Figures 2-5) . Finally, HBx functions to stabilize and promote CRTC1 activation of HBV transcription (Figures 6 and 7) . Our findings reveal a new cellular accessory factor and a new layer of regulation in HBV gene expression.

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