Selected article for: "CRTC1 HBx mutual stabilization and mutual stabilization"
Author: Tang, Hei-Man Vincent; Gao, Wei-Wei; Chan, Chi-Ping; Cheng, Yun; Chaudhary, Vidyanath; Deng, Jian-Jun; Yuen, Kit-San; Wong, Chun-Ming; Ng, Irene Oi-Lin; Kok, Kin-Hang; Zhou, Jie; Jin, Dong-Yan
Title: Requirement of CRTC1 coactivator for hepatitis B virus transcription
  • Document date: 2014_11_10
    • ID: qtoygz6w_6
    Snippet: In this study, we documented the requirement of CRTC1 in HBV transcription. CRTC1 protein was more abundantly detected in liver tissues of HBV-infected individuals. The HBV-induced stabilization of CRTC1 protein was further validated. We provided the first evidence that CRTC1 and its homologs CRTC2 and CRTC3 cooperate with HBx to activate HBV transcription through CREB. Our work suggests a new model in which HBV, through mutual stabilization of H.....
    Document: In this study, we documented the requirement of CRTC1 in HBV transcription. CRTC1 protein was more abundantly detected in liver tissues of HBV-infected individuals. The HBV-induced stabilization of CRTC1 protein was further validated. We provided the first evidence that CRTC1 and its homologs CRTC2 and CRTC3 cooperate with HBx to activate HBV transcription through CREB. Our work suggests a new model in which HBV, through mutual stabilization of HBx and CRTC1, usurps CRTC1 transcriptional coactivator to augment CREB-mediated activation of HBV transcription.

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