Research Communications of the 24th ECVIM-CA Congress

No significant clinical improvement was evident following treatment with antibiotics, glucocorticoids, topical ciclosporin or heparin. One dog died of cardiopulmonary arrest in the hospital and the two other dogs were euthanized due to progressive clinical signs. Post-mortem evaluation of the affected dogs revealed multiple abnormalities including severe proliferative fibrinous lesions affecting the trachea, larynx and epicardium, and multiple fibrous adhesions throughout the thoracic and abdominal cavities. The male dog had internal hydrocephalus and lacked a cerebellar vermis. This is the first report of ligneous membranitis in related dogs and the first report in Scottish Terriers. Sequencing the plasminogen gene in the affected dogs, their parents and unrelated control dogs to identify polymorphisms or mutations that may be associated with ligneous membranitis in dogs is ongoing.