Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_267
Snippet: Twenty-five cases were identified. 18/25 were female. Median age of occurrence was 9 years (2-17). Diagnosis was made by histology in 11/25; proliferation indices were defined in only 4 dogs. Fourteen cases exhibited metastasis at initiation of therapy. PFS for all cases ranged from 8-1275 days. Median/mean PFS (days) according to treatment was M:141/317d (n = 15), MP:142/389d (n = 7), MPC:49/57d (n = 3). Median/mean PFS according to metastasis s.....
Document: Twenty-five cases were identified. 18/25 were female. Median age of occurrence was 9 years (2-17). Diagnosis was made by histology in 11/25; proliferation indices were defined in only 4 dogs. Fourteen cases exhibited metastasis at initiation of therapy. PFS for all cases ranged from 8-1275 days. Median/mean PFS (days) according to treatment was M:141/317d (n = 15), MP:142/389d (n = 7), MPC:49/57d (n = 3). Median/mean PFS according to metastasis status was M0:141/324d (n = 11) and M1:103/291d (n = 14). Dogs who underwent previous surgery (n = 10) had a median/mean PFS of 108/344d compared to those who had no surgery 119/280d. Looking at remission status, median PFS of patients who achieved a complete remission was not reached, with a mean PFS of 617d (n = 9). Median/mean PFS of patients with partial remission was 86/176d (n = 11), stable disease 49/57d (n = 2), and progressive disease 12/17d (n = 3). 19/25 cases experienced suspected adverse events. Three dogs, two of which ultimately died, had seven grade 3-5 adverse events (anaemia (n = 3), hepatotoxicity (n = 3), gastrointestinal toxicity (n = 1)).
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