Title: Research Communications of the 24th ECVIM-CA Congress Document date: 2015_1_10
ID: r59usk02_282
Snippet: The author received a travel scholarship from Zoetis to attend this congress. The incidence of melanocytic lesions is increasing among canine population. Canine malignant melanoma could have an aggressive behavior, metastasize early in the course of the disease and be resistant to most current therapeutic regimens leading to the need of finding markers with potential as therapeutic targets. The overexpression of COX-2 seems to play a key role in .....
Document: The author received a travel scholarship from Zoetis to attend this congress. The incidence of melanocytic lesions is increasing among canine population. Canine malignant melanoma could have an aggressive behavior, metastasize early in the course of the disease and be resistant to most current therapeutic regimens leading to the need of finding markers with potential as therapeutic targets. The overexpression of COX-2 seems to play a key role in melanocytic tumours, having being described an association between high COX-2 immunoexpression and the malignant behavior. In order to contribute to the understanding of the role of COX-2 in melanocytic tumours, three main pathways were investigated: angiogenesis, tumour cell proliferation and inflammatory microenvironment (T-lymphocytes and macrophages).
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