Research Communications of the 24th ECVIM-CA Congress

The low molecular weight poultry feather hydrolyzed proteinbased dry extruded diet a appears to be effective in the management of idiopathic IBD without any concurrent immunosuppressive drug over the 10 week period of this pilot study. These preliminary findings should be confirmed by a prospective, randomized double blind study. Feline pancreatitis is the most common exocrine pancreatic disorder with varied mortality. However, there is no available and reliable method to evaluate the severity and prognosis of the disease. Ninety-two cats diagnosed as pancreatitis with acute onset of compatible clinical signs and a positive SNAP â fPL TM Test between October 2011 and September 2013 were enrolled in this study. All Cats were divided into survival (n = 48) and nonsurvival (n = 44) groups. Fifty-two parameters including signalments, clinical signs, physical examinations, clinicopathological examinations, diagnostic images, complications and concurrent diseases were analyzed and compared between the two groups. Parameters with P ≤ 0.05 were considered for further analyses. The mortality in this study was 47.8%. Hematocrit, albumin, BUN, creatinine, total bilirubin, calcium, phosphorous, body temperature, systolic blood pressure, the body cavity fluids, complications, e.g. systemic inflammatory response syndrome (SIRS) and acute renal failure (ARF) were found to be significantly associated with disease severity and prognosis, and were selected for constructing the scores. Continuous variables outside the reference interval were separated into quartiles to yield quartile-specific odds ratios (ORs) for survival. Based on the integer value of the OR, the scoring system was then developed by incorporating weighting factors assigned to each quartile. A predictive total score was calculated for each cat by summing all weighting factors. The total scores of each cat ranged from 12 to 83. The severity scores in this study achieved an area under receiver operating characteristic (AUROC) of 0.88. The optimal cut-off point for discriminating outcome was 32.5 with the sensitivity of 89.6% and specificity of 77.3%, respectively. The mortality was 87.2% with a score ≥ 33, whereas 18.9% with a score ≤ 32. There was significant difference (P < 0.001) between the two groups of the cut-off point. Furthermore, the mortality reached to 100% when the score more than 56. The severity scoring system of this study provides a reliable and clinical applicable method to predict clinical outcome in cats with pancreatitis.