Selected article for: "Bat SARSr cov and SARSr cov"

Author: Longxian Lv; Gaolei Li; Jinhui Chen; Xinle Liang; Yudong Li
Title: Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13
  • Document date: 2020_3_2
  • ID: 3h1o0oz3_3
    Snippet: The genetic information of a virus is essential for not only its classification and traceability, but also its pathogenicity. At the whole genome level, the sequence identify of SARS-CoV-2 was 50% to MERS-CoV, 79% to SARS-CoV, 88% to two bat-derived SARS-like coronaviruses, Bat-SL-CoVZC45 and Bat-SL-CoVZXC21 (collected in 2018 in Zhoushan, China) , and 96% to Bat-SARSr-CoV RaTG13 (collected in 2013 in Yunnan, China) (5) . Each genome of all SARS-.....
    Document: The genetic information of a virus is essential for not only its classification and traceability, but also its pathogenicity. At the whole genome level, the sequence identify of SARS-CoV-2 was 50% to MERS-CoV, 79% to SARS-CoV, 88% to two bat-derived SARS-like coronaviruses, Bat-SL-CoVZC45 and Bat-SL-CoVZXC21 (collected in 2018 in Zhoushan, China) , and 96% to Bat-SARSr-CoV RaTG13 (collected in 2013 in Yunnan, China) (5) . Each genome of all SARS-CoV-2 strains now submitted online contains nearly 29,900 nucleotides (nt), which are predicted with at least 14 open reading frames (ORFs) (5′ to 3′), such as ORF1ab (P, 21,291 nt), spike (S, 3,822 nt), ORF3a (8,28 nt), envelope (E, 228 nt), membrane (M, 669nt), ORF8 (366 nt), and nucleocapsid (N,1,260 nt) (6) . Among them, the spike gene encoded a glycoprotein that is crucial for determining host tropism and transmission capacity, and highly divergent when compared with that of bat-SARSr-CoV RaTG13 (93.1% nucleotide identity) (6, 7) .

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