RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

In the tachypacing‐induced model miR‐1, miR‐208a, miR‐208b and miR‐499 were up‐regulated, whilst miR‐21 was down‐regulated in both heart and blood samples. MiR‐29 was up‐regulated in heart samples, while down‐regulated in blood samples whilst miR‐133a showed the opposite tendency. In blood samples of clinical patients the same expression pattern could be observed and the results were significant (p<0,05) except miR‐21. Based on the selected microRNAs, clinical cases could be clearly differentiated from healthy dogs using their microRNA expression profile in blood samples. Moreover clinically asymptomatic cases with tachycardiomyopathy could be identified.