Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response Document date: 2018_12_4
ID: ng5c7xai_31
Snippet: Reprogramming protein synthesis is a central strategy by which mammalian cells achieve energy conservation and adapt to stressful environments. To our knowledge, the mechanism of prioritizing stress protein translation by 2-5AMD is different from mechanisms of previously described mammalian pathways. Whereas mammalian protein synthesis is usually regulated by interference with translation initiation factors (Iwasaki et al., 2016; Marques-Ramos et.....
Document: Reprogramming protein synthesis is a central strategy by which mammalian cells achieve energy conservation and adapt to stressful environments. To our knowledge, the mechanism of prioritizing stress protein translation by 2-5AMD is different from mechanisms of previously described mammalian pathways. Whereas mammalian protein synthesis is usually regulated by interference with translation initiation factors (Iwasaki et al., 2016; Marques-Ramos et al., 2017; Taniuchi et al., 2016) , 2-5AMD acts directly on messenger RNAs. If global mRNA decay is matched with a complementary transcriptional response, the transcriptional induction can outpace the decay. In the described example, activation of this mechanism orchestrates cell commitment to the IFN response.
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