Author: Tarakhovsky, Alexander; Prinjha, Rab K.
Title: Drawing on disorder: How viruses use histone mimicry to their advantage Document date: 2018_7_2
ID: ti0avcqy_30
Snippet: Overall, in silico analyses show the presence of the histone-like sequences in numerous DNA and RNA viruses. For example, the core protein of the yellow fever virus (YFV), which contributes to virus assembly but also accumulates in the nucleus of the infected cells (not depicted), possesses impressive homology to the histone H4 as well as other histone proteins (Fig. 2 C) . The YFV core is intrinsically disordered and features lysine residues tha.....
Document: Overall, in silico analyses show the presence of the histone-like sequences in numerous DNA and RNA viruses. For example, the core protein of the yellow fever virus (YFV), which contributes to virus assembly but also accumulates in the nucleus of the infected cells (not depicted), possesses impressive homology to the histone H4 as well as other histone proteins (Fig. 2 C) . The YFV core is intrinsically disordered and features lysine residues that are spaced in a fashion similar to histone H4. Moreover, our unpublished studies show that the YFV core is acetylated in infected cells and binds to nuclear proteins in a fashion similar to acetylated histone H4.
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