Selected article for: "broad spectrum and effective treatment"
Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo
  • Document date: 2016_3_14
    • ID: pwlybr2h_2
    Snippet: Extensive efforts have been made in the search for effective preventative and treatment measures for hantavirus infections [1, 7] . Ribavirin is a broad-spectrum synthetic nucleoside analog that has been reported to effectively inhibit the replication of the Hantaan virus (HTNV, an Old World hantavirus) and Andes virus (ANDV, a New World hantavirus) in vitro and in vivo [8] . However, there are currently no prophylactic vaccines or therapeutic an.....
    Document: Extensive efforts have been made in the search for effective preventative and treatment measures for hantavirus infections [1, 7] . Ribavirin is a broad-spectrum synthetic nucleoside analog that has been reported to effectively inhibit the replication of the Hantaan virus (HTNV, an Old World hantavirus) and Andes virus (ANDV, a New World hantavirus) in vitro and in vivo [8] . However, there are currently no prophylactic vaccines or therapeutic antivirals for hantavirus infection that are approved by the FDA. Therefore, the exploration of novel treatment strategies for hantavirus infection is urgent and necessary.

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