Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_23
Snippet: Subsequently, systems biology approaches have been extended to influenza and other vaccine studies. Identifying molecular mechanisms of influenza vaccine-induced immunity was more challenging than the yellow fever vaccine study, given that the variation in antigenic match between the vaccine and circulating influenza strains can contribute to vaccine efficacy. Nakaya, et al. 71 compared transcriptomic data for those given either the trivalent inf.....
Document: Subsequently, systems biology approaches have been extended to influenza and other vaccine studies. Identifying molecular mechanisms of influenza vaccine-induced immunity was more challenging than the yellow fever vaccine study, given that the variation in antigenic match between the vaccine and circulating influenza strains can contribute to vaccine efficacy. Nakaya, et al. 71 compared transcriptomic data for those given either the trivalent influenza vaccine (TIV) or the live attenuated influenza vaccine (LAIV). Both vaccines induced the expression of genes involved in innate immune pathways, although LAIV induced higher expression of several interferon-related genes, similar to another live attenuated vaccine, YF17D. Therefore, these data demonstrated that live and dead influenza vaccines clearly result in differential vaccine-induced immunity.
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