Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_24
Snippet: Among many factors that determine the efficacy of vaccines, the age of vaccinees is the most important. In fact, older adults and children are most vulnerable to severe and often lethal influenza virus infection, due to decreased vaccine efficacy. Thus, the use of adjuvants can be helpful to improve the efficacy of influenza virus vaccines for children and older adults. [83] [84] [85] In support of this idea, Nakaya, et al. 75 conducted blood tra.....
Document: Among many factors that determine the efficacy of vaccines, the age of vaccinees is the most important. In fact, older adults and children are most vulnerable to severe and often lethal influenza virus infection, due to decreased vaccine efficacy. Thus, the use of adjuvants can be helpful to improve the efficacy of influenza virus vaccines for children and older adults. [83] [84] [85] In support of this idea, Nakaya, et al. 75 conducted blood transcriptome analysis in children less than 2 years old to compare the immunogenicity of TIV with and without MF59 adjuvant, an oil-in-water adjuvant known to increase the magnitude of the antibody response to inactivated vaccines. Interestingly, the more potent antibody responses generated in subjects receiving MF59-adjuvanted vaccines correlated with strong transcriptional signatures of interferon signaling network in blood samples.
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