Author: Gong, Shu-ran; Bao, Lin-lin
Title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models Document date: 2018_7_28
ID: zy8qjaai_28
Snippet: Another suitable and well-established model is the common marmoset (Saguinus mystax), which can show more severe clinical signs than rhesus macaques when infected with MERS-CoV. [30] [31] [32] When administered through a combination of intraoral, intranasal and intravascular inoculation, with doses ranging from 5 9 10 6 TCID 50 to 5 9 10 7 PFU, mild to moderate respiratory disease was observed, and interstitial pneumonia was observed clinically a.....
Document: Another suitable and well-established model is the common marmoset (Saguinus mystax), which can show more severe clinical signs than rhesus macaques when infected with MERS-CoV. [30] [31] [32] When administered through a combination of intraoral, intranasal and intravascular inoculation, with doses ranging from 5 9 10 6 TCID 50 to 5 9 10 7 PFU, mild to moderate respiratory disease was observed, and interstitial pneumonia was observed clinically and microscopically.
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