Author: Gong, Shu-ran; Bao, Lin-lin
Title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models Document date: 2018_7_28
ID: zy8qjaai_32
Snippet: In the case of cynomolgus monkeys, clinical evidence, such as lethargy, temporary skin rash or respiratory distress, has not been reported. However, 4 to 6 days post-inoculation (dpi), there was diffuse alveolar damage and extensive loss of epithelium from alveolar and bronchiolar walls. 28, 34 Regarding African green monkeys, clearance of the virus takes approximately 4 dpi, and the infection niduses are patchy. Respiratory secretions cannot acc.....
Document: In the case of cynomolgus monkeys, clinical evidence, such as lethargy, temporary skin rash or respiratory distress, has not been reported. However, 4 to 6 days post-inoculation (dpi), there was diffuse alveolar damage and extensive loss of epithelium from alveolar and bronchiolar walls. 28, 34 Regarding African green monkeys, clearance of the virus takes approximately 4 dpi, and the infection niduses are patchy. Respiratory secretions cannot accurately reflect the viral titers. However, there is a report that showed that the titer is higher and the residence time is longer in African green monkeys than in two other kinds of old world monkeys (cynomolgus and rhesus). In contrast, young BALB/c mice aged 4-6 months and 12-to 14month-old BALB/c mice displayed clinical syndromes such as weight loss, dehydration, and ruffled fur at 3-6 dpi, along with interstitial pneumonia, 36
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