Author: Grove, Joe; Marsh, Mark
Title: The cell biology of receptor-mediated virus entry Document date: 2011_12_26
ID: v4op73hf_16
Snippet: Although highly effective in many cases, the strategy of passive receptor-mediated uptake may limit the rate of entry, leaving a virus particle exposed on the cell surface. Thus, some viruses have developed the means to trigger their uptake into endocytic vesicles. Influenza A virus, for example, is internalized by both clathrin-mediated endocytosis and clathrin/caveolin-independent mechanisms (Rust et al., 2004) . mimic normal tissues can provid.....
Document: Although highly effective in many cases, the strategy of passive receptor-mediated uptake may limit the rate of entry, leaving a virus particle exposed on the cell surface. Thus, some viruses have developed the means to trigger their uptake into endocytic vesicles. Influenza A virus, for example, is internalized by both clathrin-mediated endocytosis and clathrin/caveolin-independent mechanisms (Rust et al., 2004) . mimic normal tissues can provide new insights to infection mechanisms. Significantly, both coxsackievirus B and adenovirus type 2 entry require the activation of specific kinases that are potential targets for pharmacological intervention.
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