Author: Xiaoqiang Huang; Robin Pearce; Yang Zhang
Title: Computational Design of Peptides to Block Binding of the SARS-CoV-2 Spike Protein to Human ACE2 Document date: 2020_3_31
ID: imkeghfd_13
Snippet: Only structures with a TM-score ≥0.7 to the hACE2 scaffold were collected to build a pairwise multiple sequence alignment (MSA). A total of nine structural analogs were identified. The corresponding alignment for residues 22-44 and 351-357 were directly extracted from the fulllength MSA and combined to build an MSA for the hybrid peptide. Since an arbitrary glycine was used to link positions 44 and 351, a gap '-' was inserted in the peptide MSA.....
Document: Only structures with a TM-score ≥0.7 to the hACE2 scaffold were collected to build a pairwise multiple sequence alignment (MSA). A total of nine structural analogs were identified. The corresponding alignment for residues 22-44 and 351-357 were directly extracted from the fulllength MSA and combined to build an MSA for the hybrid peptide. Since an arbitrary glycine was used to link positions 44 and 351, a gap '-' was inserted in the peptide MSA for the glycine position.
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