Author: Salaun, Christine; Greaves, Jennifer; Chamberlain, Luke H.
Title: The intracellular dynamic of protein palmitoylation Document date: 2010_12_27
ID: svn4e6w6_3
Snippet: Unlike the catalysts of N-myristoylation and prenylation reactions, the enzymes that mediate palmitoylation are polytopic membrane proteins (Fukata et al., 2004; Mitchell et al., 2006) , implying that cellular palmitoylation reactions occur at the cytosol-membrane interface. There are îº23 putative S-palmitoyl transferases in mammals, characterized by the presence of a DHHC (aspartate-histidine-histidine-cysteine) motif within an îº50 amino aci.....
Document: Unlike the catalysts of N-myristoylation and prenylation reactions, the enzymes that mediate palmitoylation are polytopic membrane proteins (Fukata et al., 2004; Mitchell et al., 2006) , implying that cellular palmitoylation reactions occur at the cytosol-membrane interface. There are îº23 putative S-palmitoyl transferases in mammals, characterized by the presence of a DHHC (aspartate-histidine-histidine-cysteine) motif within an îº50 amino acid cysteine-rich domain. The large number of these DHHC proteins coupled with their localization to distinct membrane compartments (Ohno et al., 2006) implies that the cellular palmitoylation machinery is a highly regulated and coordinated system.
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