Author: Ahat, Erpan; Xiang, Yi; Zhang, Xiaoyan; Bekier, Michael E.; Wang, Yanzhuang
Title: GRASP depletion–mediated Golgi destruction decreases cell adhesion and migration via the reduction of a5ß1 integrin Document date: 2019_3_15
ID: rfs7m6or_5
Snippet: Cell attachment depends on a set of cell adhesion proteins called integrins; α5β1 integrin is the main form of integrin complex in HeLa and MDA-MB-231 cells (Mierke et al., 2011; Yu et al., 2011; Jia et al., 2016) . As highly glycosylated transmembrane proteins, α5 and β1 integrins are processed by the Golgi and transported to the plasma membrane for their proper functions. When transported through the TGN, α5 integrin undergoes posttranslat.....
Document: Cell attachment depends on a set of cell adhesion proteins called integrins; α5β1 integrin is the main form of integrin complex in HeLa and MDA-MB-231 cells (Mierke et al., 2011; Yu et al., 2011; Jia et al., 2016) . As highly glycosylated transmembrane proteins, α5 and β1 integrins are processed by the Golgi and transported to the plasma membrane for their proper functions. When transported through the TGN, α5 integrin undergoes posttranslational cleavage for activation, wherein pro-integrin α5 (∼170 kDa) is cleaved by pro-protein convertases (PCs) into heavy (∼130 kDa) and light (∼19 kDa) chains that are linked by a disulfide bond (Paule et al., 2012) . Because GRASP depletion accelerates α5-integrin trafficking and processing (Xiang et al., 2013) , it is reasonable to expect that it may also affect α5-and β1-integrin glycosylation and sorting as well as cell attachment.
Search related documents:
Co phrase search for related documents- cell adhesion and heavy kDa: 1
- cell adhesion and integrin complex: 1, 2
- cell adhesion and kDa light: 1
- cell adhesion and kDa light chain: 1
- cell adhesion and MDA cell: 1, 2, 3
- cell adhesion and plasma membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- cell adhesion and processing trafficking: 1
- cell adhesion and proper function: 1, 2
- cell adhesion and transmembrane protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell adhesion protein and GRASP depletion: 1
- cell adhesion protein and MDA cell: 1
- cell adhesion protein and plasma membrane: 1
- cell adhesion protein and processing trafficking: 1
- cell adhesion protein and transmembrane protein: 1, 2, 3
- cell attachment and disulfide bond: 1, 2
- cell attachment and Golgi process: 1
- cell attachment and GRASP depletion: 1, 2, 3, 4, 5
- cell attachment and MDA cell: 1
- cell attachment and plasma membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
Co phrase search for related documents, hyperlinks ordered by date