Author: Ahat, Erpan; Xiang, Yi; Zhang, Xiaoyan; Bekier, Michael E.; Wang, Yanzhuang
Title: GRASP depletion–mediated Golgi destruction decreases cell adhesion and migration via the reduction of a5ß1 integrin Document date: 2019_3_15
ID: rfs7m6or_6
Snippet: In this study, we found that Golgi destruction by GRASP depletion reduces α5β1-integrin protein level, which results in compromised cell activities such as decreased cell adhesion and migration. Using radioactive labeling and pulse-chase assays, we showed that decreased protein level of α5β1 integrin is due to reduced protein synthesis rather than accelerated protein degradation. Surprisingly, Golgi unstacking accelerated overall protein synt.....
Document: In this study, we found that Golgi destruction by GRASP depletion reduces α5β1-integrin protein level, which results in compromised cell activities such as decreased cell adhesion and migration. Using radioactive labeling and pulse-chase assays, we showed that decreased protein level of α5β1 integrin is due to reduced protein synthesis rather than accelerated protein degradation. Surprisingly, Golgi unstacking accelerated overall protein synthesis and cell proliferation. Our study revealed a direct link between Golgi structure, function, and cellular activities.
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