Author: Cao, Wei; Liu, Xiaosheng; Bai, Tao; Fan, Hongwei; Hong, Ke; Song, Hui; Han, Yang; Lin, Ling; Ruan, Lianguo; Li, Taisheng
Title: High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019 Document date: 2020_3_21
ID: u3gmpklc_22
Snippet: IVIg is a blood product containing polyclonal immunoglobulin G isolated and pooled from healthy donors, and it has been used for over 30 years. As a complex preparation, it contains a large number of bioactive moieties, and the entirety of its effects is not yet fully understood. IVIg of higher dose has been a choice of immunomodulatory therapy for autoimmune or inflammatory disease and for prophylaxis and treatment of severe infections, especial.....
Document: IVIg is a blood product containing polyclonal immunoglobulin G isolated and pooled from healthy donors, and it has been used for over 30 years. As a complex preparation, it contains a large number of bioactive moieties, and the entirety of its effects is not yet fully understood. IVIg of higher dose has been a choice of immunomodulatory therapy for autoimmune or inflammatory disease and for prophylaxis and treatment of severe infections, especially in immunocompromised patients [11, 12] . Several theories have been proposed to explain its potential immunomodulatory mechanisms, including Fc-mediated and Fab-mediated approaches [13, 14] . In previous studies of SARS and Middle East respiratory syndrome (MERS), IVIg therapy has exhibited various clinical benefits with good tolerance [15] [16] [17] . Considering its efficacy in improving passive immunity and modulating immune inflammation and the overall safety profile, high-dose IVIg could be considered a promising option at the early stage of clinical deterioration of patents with COVID-19.
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