Author: Zeng, Zhengyang; Zhang, Runhong; Hong, Wei; Cheng, Yuting; Wang, Huijuan; Lang, Yange; Ji, Zhenglin; Wu, Yingliang; Li, Wenxin; Xie, Youli; Cao, Zhijian
Title: Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1 Document date: 2018_1_1
ID: zilqyfjl_53
Snippet: Considering the significant difference between the extracellular and intracellular anti-HSV-1 activities of Eval418, we speculated that Eval418 may possess low cellular uptake in Vero cells and/or unfavorable intracellular localization. As shown in Figure 4f , Vero cells were incubated with FITC-labeled Eval418 at 10 μg/mL for 24 h at 37 ℃ and then examined by confocal microscopy. The result showed that FITC-labeled Eval418 hardly entered Vero.....
Document: Considering the significant difference between the extracellular and intracellular anti-HSV-1 activities of Eval418, we speculated that Eval418 may possess low cellular uptake in Vero cells and/or unfavorable intracellular localization. As shown in Figure 4f , Vero cells were incubated with FITC-labeled Eval418 at 10 μg/mL for 24 h at 37 ℃ and then examined by confocal microscopy. The result showed that FITC-labeled Eval418 hardly entered Vero cells. The poor cellular uptake of Eval418 possibly explained its low intracellular anti-HSV-1 activity.
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