Selected article for: "cleaved signal sequence and COOH terminal"

Title: The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope
  • Document date: 1992_12_2
  • ID: vznqgnzd_3
    Snippet: Blobel, unpublished results), gp210 has an estimated mass of'~ 210,000 D, 5 % of which consists of N-linked, high rnannose-type oligosaccharides (2, 37) . The deduced primary structure reveals an NH2-terminal, cleaved signal sequence of 25 residues followed by 1,861 residues of the mature gp210. The NH~-terminal 1,783 residues of mature gp210 are exposed on the intracisternal side of the pore membrane. This is followed by a transmembrane segment .....
    Document: Blobel, unpublished results), gp210 has an estimated mass of'~ 210,000 D, 5 % of which consists of N-linked, high rnannose-type oligosaccharides (2, 37) . The deduced primary structure reveals an NH2-terminal, cleaved signal sequence of 25 residues followed by 1,861 residues of the mature gp210. The NH~-terminal 1,783 residues of mature gp210 are exposed on the intracisternal side of the pore membrane. This is followed by a transmembrane segment (TM) of 21 residues and a COOH-terminal tail of 58 residues. The tail is exposed at the nuclear pore and is therefore a potential anchor for components of the NPC.

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