Author: Cereda, Maurizio; Xin, Yi; Hamedani, Hooman; Bellani, Giacomo; Kadlecek, Stephen; Clapp, Justin; Guerra, Luca; Meeder, Natalie; Rajaei, Jennia; Tustison, Nicholas J; Gee, James C; Kavanagh, Brian P; Rizi, Rahim R
Title: Tidal changes on CT and progression of ARDS Document date: 2017_6_20
ID: sncded7z_42
Snippet: Parameters for identifying severity of ARDS include oxygenation (P a O 2 /FiO 2 ratio), 3 plain chest radiography, compliance 19 and 'driving pressure' (the difference between plateau and EE pressure). 13 The presence of unstable inflation may quantify risk of regional disease progression in experimental injury; and the current patient data suggest that it may potentially also predict outcome in ARDS. In animals, unstable inflation accurately mir.....
Document: Parameters for identifying severity of ARDS include oxygenation (P a O 2 /FiO 2 ratio), 3 plain chest radiography, compliance 19 and 'driving pressure' (the difference between plateau and EE pressure). 13 The presence of unstable inflation may quantify risk of regional disease progression in experimental injury; and the current patient data suggest that it may potentially also predict outcome in ARDS. In animals, unstable inflation accurately mirrored the topographic/spatial development of secondary lung injury (figure 4); and in the retrospective patient series, a larger proportion (high-risk fraction >28%) of high-risk tissue at baseline was associated with mortality in ARDS (figure 6).
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