Title: trans-Golgi retention of a plasma membrane protein: mutations in the cytoplasmic domain of the asialoglycoprotein receptor subunit H1 result in trans-Golgi retention Document date: 1995_7_2
ID: tedj3xxz_1
Snippet: T RANSPORT of proteins through the secretory pathway appears to occur by default (Pfeffer and Rothman, 1987) . In contrast, localization to individual compartments (by retention or retrieval) requires specific signals (Pelham and Munro, 1993) , such as the carboxy-terminal sequence KDEL and the cytoplasmic motif K(X)KXX for retrieval to the ER of lumenal and membrane proteins, respectively. The determinants for retention in Golgi compartments hav.....
Document: T RANSPORT of proteins through the secretory pathway appears to occur by default (Pfeffer and Rothman, 1987) . In contrast, localization to individual compartments (by retention or retrieval) requires specific signals (Pelham and Munro, 1993) , such as the carboxy-terminal sequence KDEL and the cytoplasmic motif K(X)KXX for retrieval to the ER of lumenal and membrane proteins, respectively. The determinants for retention in Golgi compartments have so far been shown to comprise the transmembrane domain with or without flanking sequences. Proteins leaving the Golgi apparatus are sorted in the trans-Golgi network (TGN) largely by signal-dependent mechanisms into specific transport vesicles to secretory granules, apical or basolateral plasma membrane, or endosomes.
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