Author: Josset, Laurence; Zeng, Hui; Kelly, Sara M.; Tumpey, Terrence M.; Katze, Michael G.
Title: Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options Document date: 2014_2_4
ID: uz0m1o0q_12
Snippet: In conclusion, cluster analysis revealed an extensive list of functions dysregulated specifically by H7N9 or similar to findings for other IAVs, including proinflammatory cytokines, the antigen presentation pathway, and several nuclear pathways. Confirming transcriptomic distance analysis, there were more similarities between H5N1 and H7N9 responses, with 2 clusters specific to these viruses (clusters 5 and 19) , than between H7N7 and H7N9, since.....
Document: In conclusion, cluster analysis revealed an extensive list of functions dysregulated specifically by H7N9 or similar to findings for other IAVs, including proinflammatory cytokines, the antigen presentation pathway, and several nuclear pathways. Confirming transcriptomic distance analysis, there were more similarities between H5N1 and H7N9 responses, with 2 clusters specific to these viruses (clusters 5 and 19) , than between H7N7 and H7N9, since there was no gene DE specifically in response to H7N9 and H7N7 only.
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