Author: Schrom, Eva; Huber, Maja; Aneja, Manish; Dohmen, Christian; Emrich, Daniela; Geiger, Johannes; Hasenpusch, Günther; Herrmann-Janson, Annika; Kretzschmann, Verena; Mykhailyk, Olga; Pasewald, Tamara; Oak, Prajakta; Hilgendorff, Anne; Wohlleber, Dirk; Hoymann, Heinz-Gerd; Schaudien, Dirk; Plank, Christian; Rudolph, Carsten; Kubisch-Dohmen, Rebekka
Title: Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA Document date: 2017_4_13
ID: tulmnb32_14
Snippet: Tailor-made lipidoid-based formulations of this optimized ACE2 cmRNA sequence led to ACE2 protein translation directly and selectively in the liver, while the lipid-based formulation for pulmonary delivery resulted in selective ACE2 translation in the lung using the same ACE2 cmRNA......
Document: Tailor-made lipidoid-based formulations of this optimized ACE2 cmRNA sequence led to ACE2 protein translation directly and selectively in the liver, while the lipid-based formulation for pulmonary delivery resulted in selective ACE2 translation in the lung using the same ACE2 cmRNA.
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