Author: Seemann, Stefan E.; Gorodkin, Jan; Backofen, Rolf
Title: Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments Document date: 2008_10_4
ID: wtvfow2f_12
Snippet: We now recall the Pfold (33) model. In the following, a secondary structure is a set of base pairs that do not cross. Let A be a multiple alignment of the sequences s 1 . . . s n . Furthermore, let T be a given evolutionary tree and M be a prior model for the secondary structures. Thus the model provides a probability distribution on the structures, given the data (i.e. the alignment A) and the background information (i.e. the secondary structure.....
Document: We now recall the Pfold (33) model. In the following, a secondary structure is a set of base pairs that do not cross. Let A be a multiple alignment of the sequences s 1 . . . s n . Furthermore, let T be a given evolutionary tree and M be a prior model for the secondary structures. Thus the model provides a probability distribution on the structures, given the data (i.e. the alignment A) and the background information (i.e. the secondary structure background model M and the tree T):
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